Playing God in China’s mutant mice lab

Playing God in China’s mutant mice lab

Watch the new CBSN Originals “Playing God” on CBSN on Monday, November 6, at 8 p.m., 11 p.m. and 2 a.m. ET.

When it comes to genetic editing, China’s academic science apparatus does not try to hide much. On the marble exterior of this university building in Nanjing, China, the name proudly reads “National Resource Center for Mutant Mice.”

Inside, shelves house rows of what looks like plastic lunch boxes, mice whose genetic makeup has been tweaked to allow the scientists to try out different kinds of therapies. Nanjing University was one of the first academic institutions to start using CRISPR DNA-editing technology when it was discovered in 2012, and they’re charging ahead.

A scientist injects a mouse in Nanjing University’s National Resource Center for Mutant Mice. CBS NEWS
Dr. Xiang Gao and his staff edit the genomes of mice to investigate the causes of human diseases at the genetic level. They have more than 4,000 strains of CRISPR-edited mice here. They’re used for investigating cures for cancer, blindness, and even obesity in the hope that their discoveries can be translated to humans in short order.

They’re closer than most. CRISPR on human cancer patients, and Gao says more are underway.

Mice have been used for decades for initial phases of testing because their genetic makeup is close enough to that of humans to make the results useful, or at least, indicative. But when it comes to tweaking human DNA, there is still, says Gao, the “human problem.” That problem is ethical. “When you cross it, there’s no way back,” he tells CBS News.

Shalane Flanagan wins women’s New York City Marathon

Shalane Flanagan wins women’s New York City Marathon

winning the professional women’s division at the 2017 TCS New York City Marathon. Mandatory Credit: Derik Hamilton-USA TODAY Sports DERIK HAMILTON
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Last Updated Nov 5, 2017 12:50 PM EST

NEW YORK – Shalane Flanagan pulled away from Mary Keitany on Sunday to become the first American to win the women’s New York City Marathon since 1977.

Keitany had won three straight New York marathons, but Flanagan pulled away from the Kenyan great with about three miles to go. Flanagan finished with an unofficial time of 2 hours, 26 minutes, 53 seconds – about a minute faster than Keitany.

The American cried and yelled as she approached the finish line alone.

The last American woman to win New York was Miki Gorman, who won consecutive titles in 1976-77.

Flanagan finished second in New York in her first marathon in 2010 but had not run this race since. After a fracture in her lower back kept her out of the Boston Marathon, Flanagan trained hard for New York with an eye on Keitany.

Shalane Flanagan crosses the finish line first in the women’s division of the New York City Marathon in New York, Sunday, Nov. 5, 2017. SETH WENIG / AP
Flanagan called Keitany “the alpha racer” and said she was ready to “suffer dearly” while keeping up with the unpredictable Kenyan. Flanagan had said she may retire if she won New York.

More than 50,000 runners from across the globe pushed themselves to the limit to traverse each of the five boroughs over a whopping 26 miles and change, CBS New York reports.

The day was dedicated to the spirit and pride, and was marked by the presence of the police. 2.5 million spectators cheering them on along the city-spanning route.

The enhanced security was in response to the truck attack in lower Manhattan on Halloween. Eight people were killed when terror suspect Sayfullo Saipov sped down the popular bike path near the West Side Highway, mowing down innocent cyclists and pedestrians.

Finding a car to connect a son with his father, a fallen soldier

Finding a car to connect a son with his father, a fallen soldier

MOORE, Texas – Even in the United States, Justin Rozier has been thinking lately about a car. Specifically, he told his mom, Jessica, he would love to have a car – any car – that his dad once owned.

“I mean, it could have been a 1974 Dodge Astro – I do not even know if it’s a car – but it’s got to have anything and he would have said, ‘Yes,'” Jessica said.

Why? “I know that he wishes his dad was here,” Jessica answered.

Army 1st Lt. Jonathan Rozier and his son, Justin Rozier. CBS NEWS
In 2003, Justin’s dad, Army 1st Lt. Jonathan Rozier, died in Iraq. Justin was nine months old. Today, he cherishes anything that used to belong to his dad – which is why he thought it would be so cool to have his car.

“I do not know, just knowing that he has it – it’s a whole lot different than just any other thing,” Justin said.

Unfortunately, after Jon died, Jessica had to sell the car – a ’99 Toyota Celica convertible. Finding it again would be nearly impossible, but Jessica said she had to at least try.

A 1999 Toyota Celica covertible. CBS NEWS
“I feel like this is something connecting him,” Jessica said.

But this is a needle in a haystack.

“Well, I’ve seen magical things happen on Facebook,” Jessica said.

So she turned to Facebook – posted the old VIN with a note asking for help. And somehow that message made it all the way to Pleasant Grove, Utah – where the local residents not only found the car, but decided to go a step further.

“We decided, let’s see if we can buy the car,” said Kyle Fox. “So I’m always trying to do something like that to serve.”

Now, I’m not saying Kyle is a saint, but a butterfly did land on him in the middle of our interview – and stayed there for half an hour.

Kyle Fox runs a non-profit called “Follow the Flag.” CBS NEWS
“Now I do not even know where I was,” Kyle said, distracted.

Anyway, Kyle, who runs a nonprofit called Following Flag, got donations to purchase the car, and then assembled a team volunteer mechanics to fix it like new – all unbeknownst to Justin until last month, when Kyle drove the car from Utah to surprise Justin for his 15th birthday.

I can not tell you what this meant to Justin. I mean, I really can not. He tried to explain it to me, but when he opened his mouth no words fell out.

Justin Rozier in the ’99 Toyota Celica that once belonged to his father – a fallen soldier. CBS NEWS
“It’s a link to the past for him.” It’s a big thing for me too, so I just need to say that, “Justin said.

Obviously, this was never about a car. No, this is about trying to remember what you can know about the country so grateful and kind you can not imagine.

Despite conflicting analyzes, Rep. McCarthy guarantees tax cuts for everyone in the middle class

Despite conflicting analyzes, Rep. McCarthy guarantees tax cuts for everyone in the middle class

House Majority Leader Kevin McCarthy said Sunday that his party’s tax plan will cut taxes for America’s middle class, despite the fact that congressional budget scorekeepers say that likely will not be the case.

“Look, we are cutting rates.” So, this is a tax cut, “McCarthy said on CBS News” “Face the Nation.”

Transcript: Rep. Kevin McCarthy on “Face the Nation”
California’s Republican said, “Yes.” It’s a fact that the first $ 55,000 for the middle class. ”

Congressional budget analysis however has found, however, that the middle class families will likely end up paying more in the years 2023 and 2024 due to the sun setting of some provisions of the bill, including the proposed child tax credit. While the current proposal increases the child tax credit to $ 1,600 from $ 1,000, that provision is not permanent, thus costing families more in the long term.

But McCarthy said that economic growth will fix those discrepancies.

“Always in America, we’ve averaged more than 3 percent of Growth, but Bill Clinton’s Barack Obama’s “Growing the economy is the key to getting us working back and helping us to balance the budget,” said McCarthy.

“We know where the challenge is when it comes to entitlements,” he added. “We’ve got those plans out there.” We have to grow the economy and save the entitlements for the next generation by changing them to be actually prepared for the future. ”

The tax plan, which was formally rolled out last week, was criticized by the GOP as providing a break to the middle class, although critics say the benefits will overwhelmingly be enjoyed by corporations and the rich. That’s because the tax rate on corporations will be reduced to 20 percent from 35 percent, allowing the country’s largest companies to retain more of their profits.

McCarthy, however, said the tax plan will “make America competitive again.”

“For decades the hard-working Americans have been ignored or forgotten from Washington, but not anymore.” This is what McCuty says.

Most Americans would like to see a new CBS News Poll, and a majority would like to see tax increases for large corporations (56 percent) and for the wealthy (58 percent).

Meanwhile, McCarthy said he would not be opposed to seeing the Republican’s tax bill that would remove the individual mandate as written under the Affordable Care Act.

“Well, I know the people are talking about it” I know the Senate is looking at it “We will start marking up this bill in Ways and Means next week, and I look for having the bill on the floor the week after that.The Senate will come out with theirs shortly, “added McCarthy.

Nazi-era art dealer’s treasure trove debuts in Europe

Nazi-era art dealer’s treasure trove debuts in Europe

It’s an art collection like no other because it’s collected like no other.

Hundreds of pieces of art are now on display from a spectacular stash that was once hoarded by the son of a Nazi-era dealer. The artworks, including masterpieces by Monet and Rodin, are being shown for the first time since World War II this year as part of parallel exhibitions in Switzerland and Germany.

All of the exhibits were seized by the Nazis during World War II in a methodical program directed by German dealer Hildebrand Gurlitt. He led the task of poaching art from Jewish families and selling art defamed as “degenerate” overseas.

It’s a display that now sheds light on the darkest chapters of Nazi Germany, says art director Nina Zimmer.

“How they persecuted artists and art they did not like and how they did this systematically,” Zimmer says.

The works may never have been stumbled upon during a routine tax investigation at a nondescript address in Munich.

Hildebrand’s reclusive son, Cornelius Gurlitt, had hidden away a trove. The priceless Rodin sitting near a potted plant and the monet hanging on a wall.

The Rodin found in Munich
The exhibition has raised morale and ethical issues over the art’s true provenance and inspections.

Project director Andrea Baresel-Brand says that the shows can act as something of a lost and found.

“Through the broad media coverage of the exhibitions of course a wider public is reached and maybe somebody recognizes something,” Baresel-Brand says.

Even conservative estimates of the collections have been reunited with their rightful owners.

Sen. Richard Blumenthal says “enough is enough” after Texas church shooting

Sen. Richard Blumenthal says “enough is enough” after Texas church shooting
Sen. Richard Blumenthal, D-Conn., Said he is “heartbroken” for Slyerland Springs, Texas, Sunday – and he called on Congress to act.

“Horror, heartbreak, shame .Another unspeakable tragedy, Congress must act – or be complicated,” Blumenthal wrote in the wake of the shooting.

“Enough is enough,” he said. “Now is the time for commonsense gun violence prevention steps Congressional complicity must end.”

Heartbroken for victims, loved ones, and all affected by the horrific tragedy in Sutherland Springs, Texas.

– Richard Blumenthal (@SenBlumenthal) November 5, 2017
Horror, heartbreak, shame. Prayers are important but insufficient. After another unspeakable tragedy, Congress must act – or be complicit.

– Richard Blumenthal (@SenBlumenthal) November 5, 2017
Enough is enough. Now is the time for commonsense gun violence prevention steps. Congressional complicity must end.

– Richard Blumenthal (@SenBlumenthal) November 5, 2017
Blumenthal represents the state that suffered its own tragic shooting in 2012, when a gunman opened fire at Sandy Hook Elementary School in Newtown, Connecticut, killing 20 students and six teachers.

He has since become a vocal critic of members of Congress calling for “thoughts and prayers” in the wake of similar violent shootings – most recently joining the chorus of fellow senators calling for a revision in the nation’s gun laws in the days that followed last month’s Las Vegas massacre.

Oh my god. https://t.co/2Crgakq8pN

– Chris Murphy (@ChrisMurphyCT) November 5, 2017
Fellow of Connecticut Sen. Chris Murphy, who represents the district of Newtown and is another vocal critic of gun violence, tweeted his reaction to the shooting, writing, “Oh my god.”

At least 26 people were killed in the shooting, Texas Gov. Greg Abbott said in a news conference Sunday night.

The shooting suspect has been identified as 26-year-old Devin Patrick Kelley, CBS News has learned from the federal law enforcement sources.

Kelley is a former U.S. Air Force member who served from 2010 to 2014. He was dishonorably discharged and court martialed in May 2014, CBS News has learned.

Lego’s “Women of NASA” set is already a huge hit

Lego’s “Women of NASA” set is already a huge hit

Sally Ride made history back in 1983, when she became the first American woman to travel into outer space. Now, Ride and three other women who were NASA pioneers are being honored with their own Lego likenesses.

The “Women of NASA” Lego set went on sale this week, and quickly became the top-selling toy on Amazon.

Mae Jemison was the first African-American woman in space. Her figure stands alongside Ride’s next to a Lego version of the space shuttle.

But the toys do not just honor astronauts – astronomer Nancy G. Roman is also depicted. She was NASA’s first female executive and is often credited with being the mother of the Hubble Space Telescope, which transmitted stunning pictures of deep space back to earth.

Computer scientist Margaret Hamilton makes up another figurine in the set. She wrote the software code that helped the Apollo 11 crew land safely on the moon, and last year was awarded the presidential Medal of Freedom.

The women of NASA was originally thought up by science writer Maia Weinstock.

“We want to focus on NASA history,” Weinstock said.

She submitted the plans to Lego in 2016, and the project received the 10,000 votes it needed to proceed in a little more than two weeks.

By shrinking them down to a little more than an inch, Weinstock hopes these womens’ achievements will be magnified.

“You can never have enough that women celebrate women who have been underappreciated in history,” she said.

Working from home: heaven or hell?


Working from home is becoming the latest trend and we are talking globally here. Everyday, more companies let their workers work from home at least once or twice a week. And even more companies are looking to outsource, looking for workers who may work from home and, occasionally, from different countries. We can see this “work from home” work is increasing every day on different job boards and people are really starting to enter this new stream because, let’s face it, staying home should be better than going to officials every day. However, this is unused to everyone. Working from home has good and evil, but, ultimately, it depends on everyone.

Let’s start off listing some goodness: no journey, that’s the only thing that can convince you to stay home, no traffic, no public transport, no people above you at peak time, just happiness as you walk from the booth to the official room; the flexibility of working hours and in managing the time, most of these jobs do not have to have the tight schedule you need to follow, so you can set your own time, especially if you are a freelancer; Less pressure, because most people who work from home are their own bosses, or their boss is not around them, the pressure can be reduced at least; Lack of distractions resulting in more productivity, no useless encounters, no workbooks telling about 13 cats or their children, not wandering around the officials looking for a photocopier that actually works, not wasting time with small talk, just you and your family; more family time, because you are already home, there is a good chance to spend more time with your family, or your dog, while working from home, you just need to be organized and know how to manage your time in a productive way

Although now you may be ready to pack your desk and go home, you need to know that working from home also has a drawback: alienation, although some people prefer to be alone, others prefer to have some companies during the day, but if you have a family, this is not a problem; disturbance, we may have more disruptions in the officials, but that does not mean not at home, social media shipping becomes your greatest enemy when working from home; Separating work from home, this is probably one of the worst disadvantages of working from home, you should be able to manage your day in a way that can spend enough time you work and enough with your family or friends, try to have a separate room to work, do not stay in your bedroom, look for a good corner at home to do it; Working endlessly, because you do not have anybody escorting your work time but yourself, you may feel the need to work every time, that’s why you should be regular with your time and put your responsibilities first.

Stay at Home Mom and Share with Home Contents


 

Being a homeowner for small children makes it very difficult to contribute financially to the contents of the house. With price increases, it becomes very difficult to support a family with one salary, it is also a young one. Elizabeth found herself in this state. She knew perfectly well that her children needed her, but her husband also needed their support so they could live a debt-free and stress free life.

SEARCH FOR A WAY to work from home

He researched on the internet about the choices he had as a mother who wanted to work from home. Interestingly he found what he could do. He found an article on a company that launched food distribution. Curios like the rest of us, he takes a deeper approach to a topic that is very close to his heart, his food.

THE WONDERS OF THE CLONE SHARING GOOD

All aspects of this webpage work with the essence that he / she should purchase a food shopping script to run the business properly. This concept works as follows:

1. The owner of the site will list what they cook on a particular day and what the price per plate.

2. Options may be eaten at the chef or takeaway.

3. People who want to eat something different or perhaps home-cooked food will see their strings and decide the same as they see what they like if yes, then they will certify the food, how much and whether it is takeaway or meal. The online payment options available for the restaurant may be paid directly and wait if they are allowed to go and eat / take. If the restaurant were willing to pay with cash, the choice was also open.

It’s too good to be true. He also found that buying a food outsourcing script did not require much capital. She discussed this with her husband and told him that this was what she wanted to do. He fully supports it because he knows it’s important for both of them to be financially adequate.

This is the best decision they make. They are equally connected to this trade, not so with the aspects of money, but the fact that they have made so many new friends through the sharing of food.

Elizabeth had designed a schedule to keep her children undisturbed and her husband helpful when and whenever she could, both in the kitchen and with the children.

The Wang they produce helps them live the way they want and does not even bother their routine as Elizabeth sells the food she has planned to cook for the family just a little extra for the visitors. They have decided to pay back a portion of their income for a luxury bed in the nearest future.

Like Elizabeth, you can do something like this if you are looking for cash by doing something you like.

What is Business Benchmarking? Why is he important?



If you are part of a small and simple company (MCC) and have never heard of Business Creation Business, then this is the place to start. What does Business Make Business mean? Business Matchmaking is a networking event usually held by non profit organizations or educational institutions with the aim of connecting small businesses with major companies and royal agencies.

Many MCCs are often dogged by finding ways to increase their income and find ways to connect with major companies and royal agencies. Commercial Guided Service is a key opportunity for the MCC to meet with customers and have guaranteed period slots to expand their products and services.

How Businesses Make Business Work Into Work?

The show or host producer makes the decision-making event, the same as a larger exhibition / exhibition exhibition or as a typical wedding event itself.

Match type:
Open – Seller (MCC) makes a promise
Semi-Open – The seller makes an appointment, but the buyer needs to pass it
Closed – Buyers (Primary Companies / Royal Agencies) make promises based on their earnings without any input from the seller.
Custom – Event admin can mix and customize the above options to customize the event that works best for them. Inventory events summarize the type of b2bmeetings that needs to be done, the number of inaugurations each small business is given, and the period of each inauguration

commercial logos, marketing materials, social media and other related videos about their business. The event’s pilot initially opens the event registration for the buyer and the event’s sponsor. Buyers not only provide profiles of their profiles but also provide for their future and future needs regarding their goals. As good as there are enough buyer numbers, open registration for MCC.
SMB is required to purchase tickets for the event after registration. They are then asked to package their current profile with detailed information about their business, personal image,
It is important to have a complete and complete profile to maximize potential buyers’ chemicals.

Miscellaneous scheduling may be based on the type of event to be chosen by the administration. The event management company eases buyers and sellers to log in, package their profile now, and schedule their promises.
Sometimes event pamphlets may decide to make their own games while only giving buyers and sellers the power to update their profiles. At other times, they will justify the buyer, the seller, or both of them scheduling their personal resistance.
Matching may be done by justifying buyers and sellers looking for profiles and filtering companies based on criteria such as NAICS codes, commodity codes, commercial categories, diversity types, revenues, sharia sizes, and geographic locations.
Scoring – Some softwares also score on each of the corresponding criteria and then set up a company with the highest value above, making it easier to know the exact equivalent of potentially.
Auto Scheduling – Event attendees may also make the decision to schedule it when letting buyers and sellers give their choice. Based on the primacy of the buyer and seller, the Matchmaking Business of Automobiles automatically manages the resistance and the inaugural schedule using an algorithm without conflict
With the addition of App Business Comparison Businesses, buyers and sellers may soon make an appointment to fill the last minute cancellation. This app enhances productivity to fill a full schedule of events.

On the day of matchmaking, the event admin usually sets the schedule, gives the schedule number, and gives each label to know the exact matchmaker (buyer).
Buyers are checked and put forward their timetable with their respective SMB profiles they will meet. Sellers are checked and put forward their individual schedules along with the buyers directory and their needs. The ticket validation process and ticket admission alone may be done automatically using the sign-in application.
Matches usually remain immobile on their desks when SMEs move from table to table meetings with buyers encountered following their schedule, similar to a quick appointment.
There are many opportunities not just to fulfill the buyer’s needs but also to work with partners and to develop relationships